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Irina Fleischer
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CISTM14 (2015) Posters Altitude, Diving and Other Environmental Exposures PO01.01 Efficacy of Ipomea pes – caprae Ointment as an Add – on Therapy in Patient with Jellyfish Dermatitis W. Piyaphanee 1 , V. Choovichian 1 , W. Matsee 2 , K. Palakul 3 , J. Olanwijitwo ng 2 , N. Chinnarat 2 , T. Chaiyakul 4 1 Mahidol University, Department of Clinical Tropical Medicine, Bangkok, Thailand, 2 Mahidol University, Hospital for Tropical Diseases, Bangkok, Thailand, 3 Mahidol University, Department of Medical Entomology, Bangkok, Thai land, 4 Royal Thai Navy, Naval Medical Department, Bangkok, Thailand Background: Jellyfish dermatitis is a common skin problem among travelers who expose to seawater. In the tropics, the plant, Ipomea pes – caprae has been known as an effective herbal treat ment for jellyfish dermatitis. However, no clinical trial has been done to prove its efficacy. Objective: To prove the efficacy of Ipomea pes – caprae ointment as an add – on therapy in patient with jellyfish dermatitis Material and method: This was an open l abel, prospective, test of superiority efficacy trial of Ipomea pes – caprae ointment in patient with jellyfish dermatitis. Adult patients with the onset of dermatitis less than 7 days were eligible to the study. The investigator divided the dermatitis area of each patient into two parts (Test and Control). Each patient received standard medical treatment depended on the severity of dermatitis in both areas. Ipomea pes – caprae ointment was applied as an add – on only to the Patients were asked to c ome for follow up 6 times in the 28 – days study period. Primary outcome was time to non – active skin lesion while the secondary outcomes were the duration of pain and itching due to jellyfish dermatitis. Result: Forty – eight patients (19 males, 29 females) w ith jellyfish dermatitis were enrolled in this study. Their median age was 31 years, 72.9% of participants exposed to jellyfish on the day of enrollment. Nearly all patients (89%) received topical steroid, 50% received oral antihistamine while 10% received oral prednisolone as standard treatment. All participants applied Ipomea pes – caprae ointment for only test area. Time to non – active skin lesion in test and control area were 5.52 days, 5.93 days, respectively (p=0.057). There was no different in duration of pain between test area and control area (4.15 VS 4.37 days, p=0.192). However, duration of itching in test area was significantly less than the control area (3.30 VS 3.77 days, p=0.04). Overall skin outcomes were recovery without scar (59%), hyperpigmen tation(35%) and healing with scar (7%). There was no statistical significant in test and control area. Conclusion: The current result could not demonstrate the efficacy of Ipomea pes – caprae ointment in the treatment of jellyfish dermatitis. However, this ointment was effective in reducing the duration itching.
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