How to determine whether the clearance of a drug is linear

This can be done in two ways:

First method:

Plot concentration/dose versus time for all subjects and look at the descending slope. The descending slope should overlay each other for the subjects and be linear in time.

Second method:

The second method is accomplished via non-compartmental analysis (NCA) for each subject. The lambda Z values versus dose should be plotted and there should be a horizontal line. This is also true for the AUC versus dose where AUC should be relatively constant for each of the doses.