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animalcare.ubc.ca
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Page1of6 UBCAnimalCareGuidelinesSOP:ACC2012Tech10Submittedby:KrisAndrewsLastdaterevised:May2014Dateapproved:June2014Intraperitoneal(IP)InjectioninRatsandMiceSOPPurposeThisStandardOperatingProcedure(SOP)describestheprocedureofintraperitoneal(IP)
injectioninratsandmice.ThisSOPfollowstheCCAC
guidelines
foracceptable
injectionvolumesinrodents.
ResponsibilityThosetrainedpersonslistedonanapprovedAnimalCare
Committeeprotocolperformingtheprocedure.
Allanimalusers
performingIPinjectionsinrodentsmusthavesuccessfullycompleted
theUBCAnimal
Care
Services(orequivalent)Rodent
BiologyandHusbandrycourse.References
CanadianCouncil
onAnimalCare
(CCAC)guidelines(www.ccac.ca)
Recommendations
Usethemanufacturer™srecommended
routeofinjectionsincesomedrugsmayhaveadversesideeffectsorcausediscomfortifinjected
viaanonrecommendedroute. Thevolumetobeinjectedshouldbethelowestvolumepossible
andnotexceed
thecurrentrecommended
guidelines
(seechartbelow).
Allsubstancesforinjectionshould
besterilesincecontaminationcancauseinfectionandirritationatthesiteofinjectionandcauseclinicalillnessintheanimalsandaffectresearch
results.
Warmsubstancestoroomorbodytemperature
sinceinjectionofcoldsubstancescancausediscomfortanddropinbodytemperature(ifthisdoesnotdamage
drug).
Recommended
Needle
sizeandMaximumVolumeofAdministration*SpeciesNeedleGaugeVolumeMouse2527g<10ml>
fora25gram
mouse,themaximum
volumewouldbe0.25mlRat2325g<10ml>
fora250gramrat,themaximumvolumewouldbe2.5ml*Greater
than
therecommended
volumes
shouldnotbegiven
unlessjustifiedandapprovedontheAnimalCareProtocolandincreasedmonitoringforcomplicationsimplemented.
MaterialsSyringes(appropriately
sized
forinjectionvolume)
Needles(appropriatelysized
foranimal)Sterilesubstancetobeinjected
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