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Int J Clin Exp Pathol 2014;7(8):4557-4576
/ISSN:1936-2625/IJCEP0001236
Original Article
A guide to histomorphological evaluation of intestinal
Ulrike Erben
1,6*
, Christoph Loddenkemper
2*, Katja Doerfel
3, Simone Spieckermann
1,6
, Dirk Haller
4, Markus
M Heimesaat
5, Martin Zeitz
1, Britta Siegmund
1,6
, Anja A Kühl
1,6
1Department of Medicine I for Gastroenterology, Infectious Disease and Rheumatology, Campus Benjamin
Franklin,
Charité-Universitätsmedizin Berlin, Berlin, Germany;
2Pathotres Joint Practice for Pathology, Berlin,
Germany;
3Cold Spring Harbor Laboratory, New York, USA;
4Research Centre for Nutrition and Food Sciences,
Biofunctionality Unit (ZIEL), Technical University Munich, Freising-Weihenstephan, Germany;
5Institute for
Microbiology and Infectious Medicine, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin,
Germany;
6Research Center ImmunoSciences, Charité-Universitätsmedizin Berlin, Berlin, Germany.
*Equal con
-tributors.
Received June
27, 2014; Accepted July
30, 2014; Epub July 15, 2014; Published August 1, 2014
Abstract:
Emphasizing the focus of a given animal study, histopathology can overstate differences between established mod
–
inter-study comparisons. Samples of all parts of the intestinal tract from well-established mouse models of intes
–
-ity of histological changes. Chemical noxes, infection with intestinal parasites or other models where the barrier
was disturbed from outside, the luminal side, showed high levels of similarity and distinct differences to changes
in the intestinal balance resulting from inside events like altered cytokine responses or disruption of the immune
cell homeostasis. With a high degree of generalisation and maximum scores from 4
-8 suitable scoring schemata
mouse researchers, microbiologists and pathologists we provide an easy-to-use guideline evaluating histomorphol
–
-topathologies in human disease.
Keywords: Introduction
-ed to our understanding of the pathogenesis of
-ders. Even if none of the individual models rep
-resents all aspects and stages i.e. of ulcerative
colitis mostly restricted to the colon mucosa or
of Crohn™s disease affecting the whole gastroin
–
they became indispensable to rationalise and
–
-atic attempts structuring the diversity, animal
models are grouped by the mode of induction of
of exogenous agents, genetic models and
immunological strategies
, by the mode of
-nents contributing to an IBD-like course
or by immunological mechanisms driving the
Histomorphology of the gastrointestinal tract
reliably assesses the tissue architecture and
the cellular composition even from small sam
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