Here is your pdf: The Creosote Bush Smells like Rain-Where there is None

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5Summer 2008Can I can my own salsa recipe?

Salsas are usually mixtures of acid and low-acid ingredients; they are an example of an acidified food. The specific recipe,

and sometimes preparation method, will determine if a salsa can be processed in a boiling water canner or a pressure canner. A

process must be scientifically determined for each recipe. The

National Center for Food Preservation at the University of Georgia Extension has science-based recipes and information on canning, freezing and preserving many types of foods.Is it safe to process food in the oven?No. This can be dangerous because the temperature will vary

according to the accuracy of oven regulators and circulation of heat. Dry heat is very slow in penetrating into jars of food. Also, jars

explode easily in the oven.Can food be re-canned if the lid does not seal?Canned food can safely be re-canned if the unsealed jar is

discovered within 24 hours. To re-can, remove the lid and check the jar-

sealing surface for tiny nicks. Change the jar; if necessary, add a new

treated lid and reprocess using the same processing time.Visit our website at cals.arizona.edu/maricopa/fcs/foodpres.htm for

recipes and information on preserving foods and a link to the National

Extension Food Preservation website which includes freezing, canning

recipes for vegetables, meats and mixtures foods like salsa and soups.

You can also call your local Cooperative Extension office or the UA

Cooperative Extension in Maricopa County at 602-470-8086 ext 341 to

have questions answered.Sources: So Easy to Preserve and USDA Complete Guide to Home Canning

, National Center for Food Preservation, University of Georgia www.uga.

edu/nchfp/Creosote bush (Larrea tridentata) is an amazing plant. It can live for thousands of years. As the central stems die or are broken

off, new stems sprout around the edge, eventually forming a circle

of clones. The leaves contain chemicals making it unpalatable to

most animals. Some say ‘the creosote bush smells of rain’ – or

does the rain smell of creosote bush? Perhaps it depends on how long you’ve been in the desert. Either way, you are unlikely to see

a creosote bush experiencing significant browsing by animals. Some insects can tolerate its chemical defenses, but livestock and other mammals find it highly distasteful and shun it. Try rubbing and

smelling the leaves and you’ll see why.

Creosote bush can grow in the driest hot US deserts, where no other shrubs can survive. It can extract moisture from parched soil through its extensive root system. The leaves can withstand high

temperatures and dehydration. It needs plenty of soil air for root growth and is rarely found in areas of poor drainage or moderate rainfall. Temperatures a few degrees below freezing can break the

water columns that draw nutrients up from roots to the leaves. This

break causes ‘cavitation’ of the ‘xylem vessels’ – a damaging event

which can kill plants. This helps explain its absence from the cold

deserts of Utah and Nevada.If you drive along I -10 across Arizona and into New Mexico,

take a look at the creosote bushes near the road. See how the soil around their stems can be several inches higher than the soil fur-ther away. This is ‘pedestalling’ – the base of the plant has become

perched above the rest of the ground. It’s a sign of soil erosion,

caused by wind or water. Many creosote bush areas have little

grass and herb cover, so little protection from erosion exists except

close to the creosote bushes, where some dust may be caught. Did the creosote bush reduce the grass cover, or did loss of grass

let the creosote bush in? Perhaps both. But the effect remains

– significant soil loss.Remember when you smelled the leaves? Imagine drinking creosote bush tea. Yes, it has been done, as herbal remedies rang-

ing from treating kidney stones to use as an emetic. However, its

pharmacology is not well understood and some studies suggest it can cause liver and kidney damage.So whether you see the creosote bush as just another desert plant or find its aroma intriguing in the rain, we can all respect its tenacity, its ability to thrive where few of its peers can. Many of

these bushes may outlive our grandchildren and survive droughts that occur only once in a thousand years.The Creosote Bush Smells Like Rain—

Where There is NoneSteve Woods, Graduate Student; Steve Archer, Ph.D., Professor; and Larry Howery,

Ph.D., Range Management Extension Specialist; all with the School of Natural

Resources, University of Arizona

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Here is your pdf: Historical Painting Techniques, Materials, and Studio Practice

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Here is your pdf: MetaDefender Core – OPSWAT

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Here is your pdf: Weekly – High price to pay – Palo Alto

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PaloAltoOnline.com

Candidates

file for council,

school board

Pages 5, 7

Spectrum 16 Eating Out 26 Shop Talk 27 Movies 28 Puzzles 48

Arts

Augmented reality enhances Cantor show

Page 23

Home Artisans’ home wares are uniquely made

Page 30

Sports

Vikings’ football gets a new coach

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Palo

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PRICE

TO PAY

INSIDEINSIDECity of Palo Alto Enjoy! classesPalo Alto Festival of the Arts

Palo Alto

struggles

to provide

affordable

housingPage 18Vol. XXXVII, Number 46

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Here is your pdf: A good practice guide to the administration of substances and removal of blood, including routes and volumes

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JOURNALOFAPPLIEDTOXICOLOGY

J.Appl.Toxicol.

21,15±23(2001)

AGoodPracticeGuidetotheAdministration

ofSubstancesandRemovalofBlood,

IncludingRoutesandVolumes

Karl-HeinzDiehl

1,RobinHull

2,DavidMorton

3,RudolfP®ster

4,YvonRabemampianina

5,DavidSmith

6,*,Jean-MarcVidal

7andCorvandeVorstenbosch

81Aventis,POBox1140,D35001Marburg,Germany

2NIBSC,BlanchLane,SouthMiimms,PottersBar,HertfordshireEN63QG

3TheUniversityofBirmingham,MedicalSchool,Edgbaston,BirminghamB152TT

4NovartisPharmaAG,CH-4002Basel,Switzerland

5CentredeRechercheP®zer,Etablissementd’Amboise,Z1Poce

Â-sur-Cisse-BP15937401AmboiseCedex,France

6AstraZenecaR&DCharnwood,BakewellRoad,Loughborough,LeicsLE115RH

7Aventis,102RoutedeNoisy,95235RomainvilleCe

Âdex,France

8NVOrganon,POBox20,5340BHOss,Netherlands

Keywords:bloodvolumes;bloodremoval;administrationsubstances;laboratoryanimals;re®nement.

ThisarticleistheresultofaninitiativebetweentheEuropeanFederationofPharmaceuticalIndustries

Associations(EFPIA)andtheEuropeanCentrefortheValidationofAlternativeMethods(ECVAM).

Itsobjectivesaretoprovidetheresearcherinthesafetyevaluationlaboratorywithanup-to-date,easy-

to-usesetofdatasheetstoaidinthestudydesignprocesswhilstatthesametimeaffordingmaximum

welfareconsiderationstotheexperimentalanimals.

AlthoughthisarticleistargetedatresearchersintheEuropeanPharmaceuticalIndustry,itis

consideredthattheprinciplesunderpinningthedatasetsandre®nementproposalsareequallyapplicable

toallthosewhousethesetechniquesonanimalsintheirresearch,whetherinresearchinstitutes,

universitiesorothersectorsofindustry.Theimplicationsofthisarticlemayleadtodiscussionwith

regulators,suchasthoseresponsibleforpharmacopoeialtesting.

Therearenumerouspublicationsdealingwiththeadministrationoftestsubstancesandtheremoval

ofbloodsamples,andmanylaboratoriesalsohavetheirown`in-house’guidelinesthathavebeen

developedbycustomandpracticeovermanyyears.WithinEuropeanUnionDirective86/609EEC

1wehaveanobligationtore®neexperimentstocausetheminimumamountofstress.Wehopethatthis

articlewillprovidebackgrounddatausefultothoseresponsibleforprotocoldesignandreview.

Thisguideisbasedonpeer-reviewedpublicationswheneverpossible,butwherethisisnotpossible

wehaveused`in-house’dataandtheexperienceofthoseontheworkingparty(aswellashelpful

commentssubmittedbytheindustry)fora®nalopinion.Theguidealsoaddressesthecontinuingneed

tore®nethetechniquesassociatedwiththeadministrationofsubstancesandthewithdrawalofblood,

andsuggestswaysofdoingso.Data-sharingbetweenlaboratoriesshouldbeencouragedtoavoid

duplicationofanimalwork,aswellassharingpracticalskillsconcerninganimalwelfareandscienti®c

problemscausedby`overdosing’insomewayoranother.Therecommendationsinthisguidereferto

the`normal’animal,andspecialconsiderationisneeded,forinstance,duringpregnancyandlactation.

Interpretationofstudiesmaybeconfoundedwhenlargevolumesareadministeredorexcessivesampling

employed,particularlyifanaestheticsareused.Copyright

ã2001JohnWiley&Sons,Ltd.

GOODPRACTICEGUIDEFOR

ADMINISTRATIONOFSUBSTANCES

IntroductionDosingofexperimentalanimalsisnecessaryfora

varietyofscienti®cinvestigationsandtomeetregulat-

*Correspondenceto:DrDavidSmith,SeniorDirector,Toxi-

cology,AstraZeneca,R&DCharnwood,BakewellRoad,Lough-

boroughLE115RH

Received6February2000

CopyrightÓ2001JohnWiley&Sons,Ltd.

Accepted27September2000

orydemands.Thepharmaceuticalindustry,inparti-

cular,hasinvestigatedthelevelsofdosingcompatible

withanimalwelfareandvalidscience.

2Inthepreclini-

calstageofthesafetyevaluationofnewdrugsitis

normalpracticetousemultiplesofthe`effectivedose’

inordertoattempttoestablishthenecessarysafety

margins.Wherechemicalsareoflowtoxicityorare

onlypoorlysolubleinacceptableformulations,alarge

volumemayberequiredtobegiventoindividual

animalstosatisfybothscienti®candregulatoryrequire-

ments.Theintendedclinicalusemayalsohavean

impactontheacceptabilityoflargerthanusualdose

volumes,e.g.imagingagentsorplasmaexpandersfor

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Here is your pdf: A Roadmap to Interstellar Flight

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A Roadmap to Interstellar Flight Philip Lubin Physics Dept, UC Santa Barbara lubin@deepspace.ucsb.edu submitted JBIS April 2015 Current version Ðv (4/6/16) Abstract Ð In the nearly 60 years of spaceflight we have accomplished wonderful feats of exploration

that have shown the incredible spirit of the human drive to explore and understand our universe. Yet in those 60 years we have barely left our solar system with the Voyager 1 spacecraft launched in 1977 finally leaving the solar system after 37 years of flight at a speed of 17 km/s or less than 0.006% the speed of light. As remarkable as this,

to reach even the nearest stars with our current propulsion

technology will take 100 millennium. We have to radically rethink our strategy or give up our dreams of reaching the stars, or wait for technology that does not currently exist. While we all dream of human spaceflight to the stars in a way romanticized in books and movies, it is not within our power to do so, nor it is clear that this is the path we should choose. We posit a path forward, that while not simple, it is within our technological reach. We propose a roadmap to a program that will lead to sending relativistic probes to the nearest stars and will open up a vast array of possibilities of flight both within our solar system and far beyond. Spacecraft from gram level complete spacecraft on a wafer (Òwafer

satsÓ) that

reach more than ! c and reach the nearest star in 20 years to spacecraft with masses more than 10

5 kg (100 tons) that can reach speeds of greater than 1000 km/s. These systems can be propelled to speeds

currently unimaginable with existing propulsion technologies. To do so requires a fundamental change in our thinking of both propulsion and in many cases what a spacecraft is. In addition to larger spacecraft, some capable of transporting humans, we consider functional spacecraft on a wafer, including integrated optical communications, imaging systems, photon thrusters, power and sensors

combined with directed energy propulsion. The costs can be amortized over a very large number of

missions beyond relativistic spacecraft as such planetary defense, beamed energy for distant spacecraft,

sending power back to Earth, stand-off composition analysis of solar system targets, long range laser communications, SETI searches and even terra forming. The human factor of exploring the nearest stars

and exo-planets would be a profound voyage for humanity, one whose non-scientific implications would

be enormous. It is time to begin this inevitable journey far beyond our home.

. 1 -Introduction: Nearly 50 years ago we set foot on the surface of the moon and in doing so opened up the vision and imaginations of literally billion of people. The number of children ennobled to dream of

spaceflight is truly without equal in our history. Many reading this will remember this event or look

back at the grainy images with optimism for the future. At the same time we sent robotic probes

throughout our solar system and took images of distant galaxies and exoplanet signatures that are

forever engrained in our minds. One of humanities grand challenges is to explore other planetary

systems by remote sensing, sending probes, and eventually life. Within 20 light-years of the Sun, there

are over 150 stars and there are known to be a number of planets around at least 12 of these stars and at

least 1

7 stars in 14 star systems appear to be capable of supporting planets in stable orbits within the

“habitable zone”. This is an incredibly rich environment to explore. Even within the outer reaches of our

solar system and into the beginnings of interstellar space lay a profoundly interesting number of objects

we would love to explore if we could. These include the Oort cloud, the heliosheath and heliopause, the

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Here is your pdf: I’m scared to be a woman – Human Rights Watch

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Here is your pdf: Instructions for Form 1023 \(Rev. December 2017\

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Application for Recognition of Exemption Under Section 501(c)(3) of the Internal Revenue Code

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Here is your pdf: Air Toxics Data Analysis Workbook

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Here is your pdf: Environmental Stewardship Plan for Replacement, Operation, and Maintenance of Tactical Infrastructure – Department of Homeland Security

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