How to determine whether the clearance of a drug is linear

This can be done in two ways:

First method:

Plot concentration/dose versus time for all subjects and look at the descending slope. The descending slope should overlay each other for the subjects and be linear in time.

Second method:

The second method is accomplished via non-compartmental analysis (NCA) for each subject. The lambda Z values versus dose should be plotted and there should be a horizontal line. This is also true for the AUC versus dose where AUC should be relatively constant for each of the doses.

How to calculate the speed of an object falling from a specific height

To do this we will be equating two types of energies. The first is potential energy which is associated with the energy of the object at a specific height. We will assume all of the energy will be converted to kinetic energy which is energy associated with the objects motion.

Potential Energy = Energy associated with an object at a specific height = mgh = mass * gravity * height

Kinetic Energy = 0.5mv^2 =0.5mvv= 0.5*mass*velocity^2

The “^” symbol is the exponential symbol in shorthand.

Note:

Potential Energy will be converted to Kinetic Energy so:

mgh = 0.5mv^2

See how mass is on both sides? This means that it does not matter the mass of the object in terms of how fast this object will get going. Final velocity will not be a function of mass.

Let’s divide both sides by m.

gh = 0.5v^2

Now, let’s calculate velocity.

gh/0.5 = 2gh =v^2

Now let’s square root both sides to remove the squared exponent.

sqrt(2gh) = velocity.

Now you know how to calculate the speed of an object if you let it go from a specific height.

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Here is your pdf: Aerospace Dimensions – Aircraft Systems and Airports

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2Aerospace Dimensions

AIRCRAFT SYSTEMSAND AIRPORTS

2Aerospace Dimensions

AIRCRAFT SYSTEMSAND AIRPORTS

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Community Gardening

in New Hampshirefrom the Ground UpForeword by: Lorraine Merrill

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Charlie French

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Spend the day, weekend, or a lifetime exploring the bountiful farm

tables, locally made products in the crafts market, and hundreds

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Spring/Summer 2012 | The Con˜uence | 1A Publication of Lindenwood University PressSpring/Summer 2012Vol. 3, No. 2

Twelve Dollars

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