Here is your PDF: Antifungal Agents; Keywords: antifungalagents spectrumofactivity,pharmacology,and clinicalindications jeniele.nett, md,phd a,b,davidr.andes, mda,b,*introduction:theevolutionofantifungaldrugtherapy

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AntifungalAgents SpectrumofActivity,Pharmacology,and ClinicalIndications JenielE.Nett, MD,PhD a,b,DavidR.Andes, MDa,b,*INTRODUCTION:THEEVOLUTIONOFANTIFUNGALDRUGTHERAPY Continuedadvancementofmedicalscienceofferslife-savingtreatmentoptionsfora varietyofhematologic,oncologic,andrheumatologicconditions.Immunosuppres- sion,acommontherapeuticside-effect,predisposespatientstoinvasivefungal infections,whichareescalatinginprevalence. 1,2Thedevelopmentofeffective,well- toleratedantifungalshaslaggedbehindtheadvancesofantibacterialtherapy. AmphotericinBdeoxycholate,anantifungaldevelopedinthe1950s,markedamajor therapeuticadvance( Box1 ).Althoughveryeffectiveforthetreatmentofnumerous DisclosureStatement:Theauthorshavenothingtodisclose. aDepartmentofMedicine,UniversityofWisconsin,Madison,WI53705,USA; bDepartmentof MedicalMicrobiology&Immunology,UniversityofWisconsin,Madison,WI53705,USA *Correspondingauthor.5211UWMedicalFoundationCentennialBuilding,1685Highland Avenue,Madison,WI53705. E-mailaddress: dra@medicine.wisc.eduKEYWORDSAntifungalSpectrumofactivity AzoleEchinocandins AmphotericinB PharmacokineticsIndicationsToxicityKEYPOINTS Thecurrentlyavailableantifungalagentsvarysignificantlyintermsofspectrumofactivity. Theechinocandinsexhibitpotentactivityagainst Candida,whereasthenewertriazoles offeranextendedspectrumofactivitythatincludes Aspergillus andemergingfilamentous pathogens. Thepharmacokineticpropertiesdifferamongtheantifungaldrugs.Importantconsider- ationsincludeabsorption,tissuesitepenetration,impactoforgandysfunctionondosing, routesofmetabolism,andtheneedfortherapeuticdrugmonitoring. ManytriazolesaremetabolizedviahepaticCYP450enzymes.DrugŒdruginteractionsare frequentandcommonenzymepolymorphismsmayleadtounpredictabledruglevels. DrugdosingandFoodandDrugAdministrationŒapprovedclinicalindicationsforindivid- ualantifungaldrugsarereviewed. InfectDisClinNAm -(2015) -Œ-http://dx.doi.org/10.1016/j.idc.2015.10.012 id.theclinics.com0891-5520/15/$Œseefrontmatter 2015ElsevierInc.Allrightsreserved.

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Here is your PDF: 01 FT cover.indd; Keywords: mp / spotlight emerging technologies: making innovation

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Spotlight EMERGING TECHNOLOGIES: MAKING INNOVATION WORK Alan Mak MP / Eben Upton / Iain Wright MP 01 FT cover.indd 121/10/2016 11:14:43

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Here is your PDF: cyberplanner; Keywords: cyber security planning guide

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Cyber Security Planning Guide

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Here is your PDF: 003-Fact Sheet-R21-cmyk_1PMS.indd; Keywords: payload spacecraft research dragon 3 2 integration

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USES Highly Responsive payload hosting Sensors/apertures up to 3.5m diameter Instruments and sensor testing Spacecraft deployment Space physics and relativity experiments Radiation effects research Microgravity research Life science and biotech studies Earth sciences and observations Materials and space environments research Rendezvous and inspection Robotic servicing DRAGON SPACECRAFT SYSTEM Fully recoverable capsule Trunk jettisoned prior to reentry 6000 kg total combined up-mass capability Up to 3000 kg down mass Payload Volume: 10 m 3 pressurized 14 m 3 unpressurized Mission Duration: 1 week to 2 years Payload Integration timeline: Nominal: L-14 days Late-load: T-9 hours Payload Return: Nominal: End-of-Mission + 14 days Early Access: End-of-Mission + 6 hours TYPICAL INTEGRATION TIMELINE ATP L: Œ 5 Mth Œ 3 Mth L-2 Mths Œ 2 Wks Launch EOM 2 wk ICD Fit Check Payload Integration Return OVERALL DRAGON TM CAPABILITIES Dragon is a free-flying, reusable spacecraft capable of hosting pressurized and unpressurized payloads. Subsystems include propulsion, power, thermal control, environmental control, avionics, communications, thermal protection, flight software, guidance, navigation & control, entry, descent & landing, and recovery. DragonLab TM Fast track to ˜ight. v.2.1

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Here is your PDF: P2509_IUCN_new.indd; Keywords: bonn challenge barometer progress: spotlight report 2017

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Bonn Challenge Barometer of Progress: Spotlight Report 2017

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Here is your PDF: Microsoft Word – CP5-Pressure.docx; Keywords: barometer 10 ····································································································· ····································· mercury ······································································································· 11

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iChapter 5 Measurement of Atmospheric Pressure CONTENTS 5.1 Definition and Units ······································································································ ····································· 1 5.1.1 Definition ··········································································································· ··················································1 5.1.2 Units ················································································································ ·····················································1 5.2 Principle of Atmospheric Pressure Measurement ········································································ ·············· 1 5.2.1 Mercury Barometer ······································································································· ····································1 (1) Principle of me rcury barometer ···························································································· ···················1 (2) Structure of the Fortin barometer·························································································· ···················2 (3) Handling precauti ons for me rcury··························································································· ················3 (4) Correction of ba rometer readings ·························································································· ··················3 (a) Corrections on index error ································································································ ··············3 (b) Corrections for temperature ······························································································· ·············3 (c) Corrections for gravity ··································································································· ·················4 5.2.2 Aneroid Instruments ····································································································· ·····································4 5.2.2.1 Aneroi d Barometer ····································································································· ·······································4 5.2.2.2 Aner oid Bar ograph ··································································································· ·········································5 5.2.3 Electroni c Barometer ···································································································· ·····································6 5.2.3.1 Cylindrical r esonator barometer ······················································································· ································6 5.2.3.2 Electrostatic capacity barometer ······················································································ ·································7 5.2.4 Reduction to Mean Sea Level ····························································································· ······························8 5.3 Maintenance ··············································································································· ······································· 10 5.3.1 Maintenance of the Mercury Barometer ················································································ ······················ 10 5.3.2 Aneroid Instruments ····································································································· ·································· 10 5.3.2.1 Aneroi d barometer ····································································································· ····································· 10 5.3.2.2 Aneroi d barogr aph ····································································································· ····································· 10 5.3.3 Electroni c Barometer ···································································································· ·································· 10 5.3.3.1 Cylindric al resonator ································································································· ····································· 10 5.3.3.2 Electrostatic capacity barometer ······················································································ ······························· 11 5.4 Calibration ··············································································································· ·········································· 11 5.4.1 Mercury Barometer ······································································································· ·································· 11 5.4.2 Aneroid Barometer ······································································································· ··································· 11 5.4.3 Electronic Barometer(Cylindrical resonator barometer, Electrostatic capacity barometer) ····················· 12 5.5 Repair ···················································································································· ·············································· 12 5.5.1 Mercury Barometer ······································································································· ································· 12

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Opioid Pharmacology F. Michael Ferrante, MD Director, Pain Management Center Professor of Clinical Anesthesiology and Medicine David Geffen School of Medicine at UCLA

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Here is your PDF: Mere Christianity By C.S. Lewis; Keywords: law 3. 4. 5. morality what christian

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Mere ChristianityBy C.S. LewisContents:Book Cover (Front) (Back)Scan / Edit NotesPrefaceBook I. Right And Wrong As A Clue To The Meaning Of The Universe1. The Law of Human Nature2. Some Objections 3. The Reality of the Law 4. What Lies Behind the Law 5. We Have Cause to Be UneasyBook II What Christians Believe1. The Rival Conceptions of God 2. The Invasion 3. The Shocking Alternative 4. The Perfect Penitent 5. The Practical ConclusionBook III. Christian Behaviour1. The Three Parts of Morality2. The “Cardinal Virtues” 3. Social Morality 4. Morality and Psychoanalysis 5. Sexual Morality 6. Christian Marriage 7. Forgiveness 8. The Great Sin 9. Charity 10. Hope 11. Faith 12. FaithBook IV. Beyond Personality: Or First Steps In The Doctrine Of The Trinity

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Here is your PDF: Sovereign Wealth Funds: Current Institutional and Operational Practices; Cornelia Hammer, Peter Kunzel, and Iva Petrova; IMF Working Paper 08/254; November 1, 2008; Keywords: wp/08/254 sovereign wealth funds: current institutional operational

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WP/08/254 Sovereign Wealth Funds: Current Institutional and Operational Practices Cornelia Hammer, Peter Kunzel, and Iva Petrova

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