Drug clearance has units of mL/min. Clearance_Total = Renal clearance (ke*Vd)+ Hepatic clearance (km*Vd) + Lung Clearance (kl*Vd) = (ke+km+kl)*Vd = k*Vd; e is for excreted; m is for metabolized and l is for lung. Cp = plasma concentration Elimination rate = Cp*Clearance_T Clearance_Total = elimination rate/Cp= k*Vd   What does the volume of distribution … Continue reading Pharmacokinetics: basics