Let’s say you know a bioexponential equation modeling the presence of drug in the serum, such that Cp=Ae^(-at)+Be^(bt). a = k12 and b = k21. To calculate the volume of the central compartment: Note that at t=0, Cp_initial. The intial Drug dose, Do, divided by Cp_o is the volume of the plasma compartment or the … Continue reading Pharmacokinetics: volume of central and tissue compartment, transfer constants and elimination rate constant from bioexponential equation